At variance

Bill Clinton was elected on an untenable premise: that it is the job of the President to manage the economy. Yes, that is what we have come to expect of Presidents; but this expectation, the author argues, is punishingly at variance with anything any President can credibly deliver[.]

In some contexts, German usage is at variance with English, e.g.: Ihr Büro ist im vierten Stock Her office is on the fourth floor